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Zyflamend - Cox 2 Inhibition for Reducing Inflammation, 60 softgel caps, (New Chapter)

Zyflamend -

60 softgel caps



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Zyflamend - Cox 2 Inhibition for Reducing Inflammation, 60 softgel caps, (New Chapter)

Free Gift For Order Over $50. Check out our gift selection.

Zyflamend is the #1 selling herbal supplement in the U.S. for healthy inflammation response. It has been clinically tested and is a doctor recommended supplement that is available in 60, 120 and 180 hexane-free softgel sizes. Zyflamend is known to promote:
  • Healthy inflammation response* 
  • Normal cardiovascular and joint function*
A Supercritical New Chapter In Inflammation Modulation* 
New Chapter's patented Zyflamend formulation represents a scientific breakthrough in promoting a healthy inflammation response.* Recent research studies suggest this may be an effective strategy to promote healthy joint function and normal cell growth.* 
 
New Chapter’s Supercritical Herbal Extracts 
“Supercritical” means Super Purity, Super Potency, Broad Spectrum, and No Chemical Solvents. We take nature’s finest herbs and then extract and highly concentrate (as high as 250 to 1) their precious ingredients. We do not isolate out single ingredients or spike our extracts with synthesized additives. We deliver the wisdom of nature with the complexity and organic nuances of the natural herb preserved for you. In fact, the supercritical process is the gentlest way to extract these delicate plant compounds in a manner to optimally preserve their potency and stability. And when you take New Chapter’s supercritical extracts, neither you, nor the environment, have to contend with chemical solvents. 
 
New Chapter has extensively researched the herbal pharmacopoeia and international medical databases and discovered that the following time- tested herbs, properly extracted and blended in the correct proportions, contain a significant number of phytonutrients that may safely and significantly promote a healthy inflammation response.*
  • Holy Basil: (Ocimum sanctum) Contains ursolic acid, which significantly enhances detoxification and promotes a healthy inflammation response.* 
  • Turmeric: Unique curcumin phytonutrient complex, synergistic with green tea, significantly multiplying each herb’s ability to promote healthy eicosanoid balance.* 
  • Ginger: Supercritical extract modulates both eicosanoid cascades and offers numerous anti-aging constituents.* 
  • Green Tea: Proceedings of the National Academy of Sciences report green tea polyphenols exert a beneficial effect on healthy eicosanoid balance.* Major university database notes green tea contains 51 phytonutrients that promote a healthy inflammation response.* 
  • Rosemary: Dual extracts offer highly concentrated, full spectrum eicosanoid balance and support detoxification.* 
  • Hu Zhang: (Polygonum cuspidatum) Richest known resveratrol source, with each daily serving delivering the approximate equivalent of six glasses of resveratrol-rich wine. 
  • Chinese Goldthread and Barberry: Unique berberine phytonutrient complex, naturally promotes a healthy inflammation response.* 
  • Oregano: Source of large number of phytonutrient modulators (31) according to USDA database.* 
  • Baikal Skullcap: Unique baicalin phytonutrient complex, naturally promotes healthy inflammation response.*


RESEARCH DATA

A Supercritical New Chapter in inflammation reduction New Chapter's patented Zyflamend formulation represents a scientific breakthrough in herbal COX-2 inhibition and inflammation reduction. Recent scientific studies suggest that inhibiting an enzyme known as cyclooxygenase-2 (COX-2) may be an effective way to reduce inflammation without the side effects associated with irreversible COX-1 inhibition.  
 
In addition, recent scientific studies also suggest that COX-2 inhibition may serve an important function in promoting normal cell growth in the colon, pancreas, breast tissue, and other organ systems. 
 
1: Nutr Cancer. 2005;52(2):202-12. 
 
Zyflamend®, a Unique Herbal Preparation With Nonselective COX Inhibitory Activity, Induces Apoptosis of Prostate Cancer Cells That Lack COX-2 Expression. 
Bemis DL , Capodice JL , Anastasiadis AG , Katz AE , Buttyan R. 
Abstract: 
 
Cyclooxygenase (COX) inhibitors have suppressive effects on several types of cancer cells including prostate cancer. In this study, we considered the potential COX-inhibitory activity of a unique anti-inflammatory herbal preparation (Zyflamend® New Chapter, Inc., Brattleboro, VT) and analyzed its effects on the human prostate cancer cell line LNCaP. COX inhibitory activity of Zyflamend was determined by a spectrophotometric-based assay using purified ovine COX-1 and COX-2 enzymes. Effects of Zyflamend on LNCaP cell growth and apoptosis in vitro were assessed by cell counting, Western blot detection of poly ADP-ribose polymerase (PARP) cleavage, and measurement of caspase-3 activity in treated and control cell extracts. Western blotting techniques were conducted to determine the effects of this herbal preparation on the expression of the cell signaling proteins, p21, androgen receptor (AR), phospho-protein kinase C (pPKC)(/), and phospho (p)Stat3. The phospohorylation status of several signal transduction phosphoproteins was profiled using a high-throughput phosphoprotein screening assay in treated cells and compared to controls. Zyflamend dramatically decreased COX-1 and COX-2 enzymatic activity. Elevated p21 expression coincided with attenuated cell growth following treatment of LNCaP cells with Zyflamend. PARP cleavage fragments were evident, and caspase-3 activity was upregulated over the control indicating the ability of Zyflamend to induce apoptosis of these cells. Androgen receptor expression levels declined by 40%, and decreases were observed in the active forms of Stat3 and PKC(/) in Zyflamend-treated LNCaP cells. Zyflamend inhibited both COX-1 and COX-2 enzymatic activities, suppressed cell growth, and induced apoptosis in LNCaP cells. However, our data suggests that the effects are likely due to COX-independent mechanisms potentially involving enhanced expression of p21 and reduced expression of AR, pStat3, and pPKC(/).

SUGGESTED USAGE
One softgel two times daily. Take in the middle of a larger meal with an 8 oz. glass of water.

 

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Zyflamend - Cox 2 Inhibition for Reducing Inflammation, 60 softgel caps, (New Chapter)

Free Gift For Order Over $50. Check out our gift selection.

Supplement Facts
Serving Size: 2 Softgels
Servings Per Container: 30

Six softgel EasyCaps contain

%DV
Rosemary (leaf) 100mg supercritical extract and 50mg extract (23% total phenolic antioxidants [TPA] – 34.5mg) 150 mg *
Turmeric (rhizome) 10mg supercritical extract (45% turmerones – 4.5mg) and 100mg ethanolic extract (7% curcuminoids – 7mg) 110 mg *
Ginger (rhizome) 54mg supercritical extract (30% pungent compounds – 16.2mg, 8% zingiberene – 4.3mg) and 46mg ethanolic extract (3% pungent compounds – 1.4mg) 100 mg *
Holy Basil (leaf) extract (2% ursolic acid – 2mg) 100 mg *
Green Tea (leaf) extract (45% polyphenols – 45mg) 100 mg *
Hu Zhang (Polygonum cuspidatum) (root and rhizome) extract (8% resveratrols – 6.4mg) 80 mg *
Chinese Goldthread (root) extract 96% berberine – 2.4mg) 40 mg *
Barberry (root) extract (6% berberine – 2.4mg) 40 mg *
Oregano (leaf) supercritical extract (4% TPA – 1.6mg) 40 mg *
Baikal Skullcap (Scutellaria baicalensis) (root) hydroethanolic extract (17–26% baicalein complex including baicalein and baicalin – 3.4-5.2mg, and 0.4-0.9% wogonin – 0.08-0.18mg) 20 mg *
*Daily Value no established.
 
Other ingredients: Olive oil- extra virgin, maltodextrin, silica, and yellow beeswax. 
 
Capsule: Gelatin, vegetable glycerine, purified water, and carob. 
 
Holy basil (Ocimum sanctum) Contains the powerful COX-2 inhibitor ursolic acid, which significantly enhances detoxification and reduces inflammation. 
 
Turmeric Unique curcumin phytonutrient complex, naturally inhibits inflammatory COX-2, synergistic with green tea, significantly multiplying anti-inflammatory effect of green tea polyphenols. 
 
Ginger Supercritical extract inhibits both inflammatory COX and 5-LO and offers numerous anti-aging constituents. 
 
Green tea Proceedings of the National Academy of Sciences report green tea polyphenols markedly reduce COX-2. Major university database notes green tea contains 51 anti-inflammatory phytonutrients. 
 
Rosemary Dual extracts offer highly concentrated, full spectrum, COX-2 inhibition and support detoxification. 
 
Hu zhang (Polygonum cuspidatum) Richest known resveratrol source, shown scientifically to inhibit inflammatory COX-2. 
 
Chinese goldthread and barberry Unique berberine phytonutrient complex, naturally inhibits inflammatory COX-2. 
 
Oregano Source of large number of anti-inflammatory compounds (31) according to USDA database. 
 
Scutellaria Unique baicalin phytonutrient complex, naturally inhibits inflammatory COX-2.
 

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Retail Price: $45.00
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Zyflamend - Cox 2 Inhibition for Reducing Inflammation, 60 softgel caps, (New Chapter)

Free Gift For Order Over $50. Check out our gift selection.

Editor's rating: 9 out of 10
User's rating: 100% 0%
PRODUCT REVIEW
"Supercritical" means super purity, super potency, broad spectrum, and no chemical solvents. We take nature's finest herbs and then extract and highly concentrate (as high as 250 to 1) their precious ingredients. We do not isolate single ingredients or spike our extracts with synthesized additives. We deliver the wisdom of nature, with the complexity and organic nuances of the natural herb preserved for you.  
 
In fact, the supercritical process extracts more beneficial organic antioxidants and other compounds than any other extraction processes. And when you take New Chapter's supercritical extracts, neither you, nor the environment, have to contend with chemical solvents.
USER'S OPINION   [ click here to rate! ]

James  "Magic!"
After years of inflammatory arthritis, fibromyalgia, and all that goes with these conditions, I've finally found something that really helps. After 2 days of taking Zyflamend, I was surprised at the amount of energy I had. I was able to do things I hadn't done in years. This stuff is MAGIC!

Jill  "Love it"
I started taking Zyflamed about 45 days ago for arthritis in my elbow, and I love it. My elbow is not aching every day and I attribute this to Zyflamed. I have also taken anti-inflammatories, and have found Zyflamed to be more affective in relieving my pain.


 

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Your Price: $25.05

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Retail Price: $45.00
Your Price: $16.99



 
Zyflamend - Cox 2 Inhibition for Reducing Inflammation, 60 softgel caps, (New Chapter)

Free Gift For Order Over $50. Check out our gift selection.

FAQ
All New Chapter Supplements 
Q. What makes your whole food vitamins and minerals better than conventional supplements?  
New Chapter’s Probiotic Nutrients™ deliver vitamins and minerals in the form of probiotically cultured whole food rather than the chemical forms found in conventional vitamin and mineral supplements. Research has shown that nutrients from cultured foods are more potent, bioavailable, and safer than the synthesized or isolated forms. Probiotic Nutrients are also the only line of nutritional supplements made with at least 70% organic ingredients and certified by a third party to the USDA’s National Organics Program. 
 
Q. Vitamins usually upset my stomach; will I have this difficulty with New Chapter's vitamins and minerals?  
Unlike conventional vitamins and minerals, New Chapter’s vitamins and minerals are food. Better yet, they are pre-digested, organic cultured food. So when you take New Chapter vitamins your stomach is NOT empty: it has inside it a good friend – cultured organic food – waiting to be comfortably digested. New Chapter’s Organic Probiotic Nutrients are also rich in ferment metabolites, bacteriocins and plant enzymes, and they are thus soothing to the entire gastrointestinal tract and promote digestion, detoxification and elimination. 
 
Q. How does New Chapter ensure the quality, purity and potency of their products?  
New Chapter’s Quality Assurance, Quality Control and Regulatory Compliance team have over 47 years combined experience divided equally between New Chapter and related industry experience. From Paul Schulick, New Chapter’s Founder & Chairman, down through the organization, all New Chapter Associates share in our commitment to quality. 
New Chapter requires that all lots of raw materials used for the manufacture of our products are tested for potency markers, heavy metal contamination and/or microbiological content. Our co-processors forward this information on a Certificate of Analysis for our approval prior to use or shipping. We randomly verify information contained on C of A’s through third-party laboratory analysis.
New Chapter does finished product testing on weights, potency, marker assays, micro and heavy metals. We also do expiration date testing on a random basis for the duration of declared shelf life: 18 months to 3 years. 
 
Q. Why are New Chapter's potencies lower than conventional pharmaceutical supplements?  
Short answer: they are not. We reject the theory that supplementation must be taken in huge doses of inert or bi-phasic isolated vitamins. It is a common misunderstanding that milligrams measure potency. They do not! Milligrams measure only weight and do not reflect cellular activity. New Chapter’s Organic Probiotic Nutrients™ deliver biotransformed vitamins and minerals in their finest cultured form, much in the same way as miso, kefir, tempeh, and yogurt. Research consistently demonstrates that New Chapter’s Organic Probiotic Nutrients are more active than conventional isolated or synthetic vitamins. 
 
Q. Does New Chapter offer supplements for children?  
New Chapter currently offers one product specifically designed for children called Immunity Take Care™ for Kids. Other products that were not specifically designed for children but may be safely administered under the guidance of a healthcare practitioner include: Wholemega™, Ginger Honey Tonic, All-Flora™ and Berry Green®. 
 
Q. Do you have a specific protocol for…  
All of New Chapter's products are formulated to support the nutritional needs of the body and maintain its healthy function and structure. The FDA prohibits us from recommending or prescribing products to individuals for disease conditions, however, we can suggest that you speak with a licensed healthcare provider familiar with nutritional supplements to see if one or more New Chapter supplements may be appropriate to optimize your health. Additionally, on our website you may view specific health support protocols by utilizing our Vitamin and Supplement Advisor designed by New Chapter’s Director of Medical Education, Dr. Taryn Forrelli. 
 
Q. Can I give New Chapter’s products to my pet?  
All of our New Chapter products are formulated for adult human beings. Please consult with a veterinarian who specializes in holistic and complimentary care to see if and at what suggested usage you may use an herbal, mushroom, or nutritional supplement product for your pet's specific needs. 
 
Q. Are any of your products made in China?  
No. 
 
Allergens 
Q. Are New Chapter's products gluten-free?  
Yes. All New Chapter products are naturally gluten-free. 
 
Q. Should I be concerned about products containing maltodextrin if I have a food allergy or sensitivity to corn?  
Generally, corn allergies or sensitivities are a response to the protein portion of the grain, and since maltodextrin is derived from corn starch, it rarely creates immune responses in individuals sensitive to corn protein. However, trace amounts of the protein may be present and we recommend that individuals speak with their health care practitioners about their personal experience with products containing maltodextrin to determine if they are appropriate.  
 
Product Usage 
Q. Can I take New Chapter products if I am also taking prescription medications?  
New Chapter® cannot provide information about combining prescription medicines with herbal or nutritional supplements. We suggest you always advise your prescribing physician or pharmacist about the use of dietary or herbal supplements. Only he or she can determine the risk for herb-drug interactions and supervise your response to the prescribed therapy*. You may also want to consider consulting with a qualified expert in herbal and nutritional therapy on this matter. For a referral database of licensed Naturopathic Physicians and Holistic Medical Doctors in your area, please visit: www.naturopathic.org or www.holisticmedicine.org.
Herb-drug interactions have been identified with respect to a handful of herbs and vitamins, however the vast majority of this information remains unknown. While herbal medicine has experienced a long history of safe use, this history has not included many of the modern pharmaceutical medications that are frequently used today. By making your health care provider aware of your supplement regimen, you are protecting yourself from any known potential interactions and allowing for any future information on this topic to come to light. 
 
Q. Can I take New Chapter products if I am pregnant or breastfeeding?  
Perfect Prenatal™, Wholemega® Prenatal, Ginger Honey Tonic, Berry Green®, Probiotic All-Flora®, Immunity Take Care®, and Bone Strength Take Care® are the only products New Chapter recommends for use during pregnancy and breastfeeding. Although many herbs and nourishing whole foods have long been used to promote health and comfort during pregnancy, the majority have simply not been thoroughly evaluated in clinical studies for safety during this cherished phase in a woman's life. Therefore, we suggest that pregnant or breastfeeding women use any of our products only after consulting with their health care provider or qualified expert in herbal and nutritional medicine. 
 
Specific Products 
Q. What is Zyflamend®?  
Zyflamend® is an extensively researched patented formulation comprised of specialized extracts of ten herbs and spices, many of which have been used for thousands of years by millions of people to promote health and longevity. The product was formulated based on a large body of scientific research showing that these ten herbs contain hundreds of plant compounds that support a healthy inflammation response.* The herbs are delivered in their whole form, as they are found in the diet, rather than isolated plant constituents, and many are extracted using supercritical carbon dioxide to concentrate the herbal constituents and maximize their effectiveness. Zyflamend® is currently being researched at Columbia University and the Cleveland Clinic. It enjoys enthusiastic world-wide support from physicians and patients alike. 
 
Q. Does Zyflamend support connective tissue health or just modulate inflammation?  
Both! Zyflamend® works to promote a healthy inflammation response, which is required for maintaining the health of joint cartilage. 
 
Sourcing, Certification & Organics 
Q. Are all of your products organic?  
Not yet! Currently, over half of our products are either certified organic or made with at least 70% organic ingredients. As a certified organic company New Chapter is committed to the organic movement and will continue to source the finest organic ingredients whenever possible. Please refer to the product label or catalog information for the organic status of individual products. 
 
Q. Are your products GMO-free?  
Approximately 75% of all New Chapter products have been verified as fully compliant to the Non-GMO Project Standard. To date, New Chapter is the only supplement company to have achieved this breadth of compliance. For more information on the Non-GMO project and the complete list of verified New Chapter products, please visit: http://www.nongmoproject.org/consumers/search-participating-products/search/?brandId=322. 
 
Q. Are New Chapter's products vegan?  
All of the following New Chapter products are considered vegan: Daily Ginger®, Baikal Skullcap, Broccolive® Plus, Berry Green™, Supercritical Diet & Energy™, Green & White Tea Force, Aloe Vera Force™, Probiotic All-Flora®, Chlorella Regularis, Rhodiolaforce 100 & 300™, Holy Basil, Smooth Food 2™, CoffeeBerry™, Probiotic Anti-Aging, and Probiotic Colon™, Candida Take Care™, Histamine Take Care™, Immunity Take Care™, Urinary Take Care™, LycoPom, and Zyflamend Vcaps, and E and Selenium. 
New Chapter’s Probiotic Nutrients™ Made with Organic Ingredients do not meet strict vegan standards as the vitamin D utilized for culturing with organic whole food ingredients in our vitamin D-containing products is derived from wool wax. 
The following Probiotic Nutrient formulas contain vitamin D: Every Man®, Every Man® II, Every Man®’s One Daily, Every Woman®, Every Woman® II, Every Woman®’s One Daily, Every Woman®’s Inner Beauty, Only One™, Perfect Prenatal™, and Tiny Tabs Multi™ and Bone Strength Take Care™. 
 
Q. Is New Chapter certified by a third-party?  
Yes, New Chapter is certified by several third parties. We are GMP (Good Manufacturing Practices) registered by NSF International, the world's leading expert in independent GMP audits and product safety. Additionally, New Chapter and many of its co-processors are certified to the standards of the USDA's National Organic Program (NOP), as well as, in certain instances, the International Federation of Organic Agricultural Movements (IFOAM) and the European Organic Standard (EEC 2092/91). The third party agency providing New Chapter's limited organic certification is by International Certification Services (ICS). Luna Nueva, our organic ginger and turmeric farm in Costa Rica, is certified biodynamic by Demeter International, the largest certification organization for biodynamic agriculture and the oldest traditional organic certification in Europe. New Chapter follows all GMP (Good Manufacturing Practices) protocols for GMP compliance and is currently operating under the FDA's guidelines as mandated in 21 CFR for the food industry Parts 100 - 169. We also have a certified Site License with Health Canada's Natural Health Products Directorate, which we renew every year. 
 
Q. Why do you use animal-based softgels instead of vegetarian capsules in many of your supercritical herbals?  
Because supercritical extracts are so highly concentrated, they will dissolve most vegetarian capsules. However, we are working with a technology that allows us to offer Zyflamend®, our best-selling supercritical herbal formula, in a vegetarian capsule.
GUARANTEE/ SHIPPING INFORMATION
Zyflamend is shipped in a discrete, unmarked package. Orders are processed immediately and usually take about 3 to 5 working days to be received. We do ask that you try it for 2 to 3 weeks to feel the full effects. Any information received is used only for order processing and shipping purposes. Your information, such as e-mail address, will never be disclosed to a third party.
 

Our Recommendations

Zyflamend Easycaps - Zyflamend Easycaps - promoting a healthy inflammation response, 180 softgel caps, (New Chapter)
Retail Price: $34.95
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Zyflamend - Cox 2 Inhibition for Reducing Inflammation, 60 softgel caps, (New Chapter)

Free Gift For Order Over $50. Check out our gift selection.

OUR RECOMMENDATIONS
Zyflamend Easycaps - Zyflamend Easycaps - promoting a healthy inflammation response, 180 softgel caps, (New Chapter)
Retail Price: $34.95
Your Price: $25.05
CosaminDS - CosaminDS - Joint Health Supplement, 72 caps, (Nutramax)
Retail Price: $45.00
Your Price: $16.99
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