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Stizm - Extreme Energy Inducing Formula, 90 caps, (Thermolife)
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Stizm -
Extreme Energy Inducing Formula, 90 caps, (Thermolife)
STIZM - Extreme Energy Inducing Formula is the most powerful and effective legal stimulant your money can buy. One look at the ingredient list and that fact becomes crystal clear. If you are looking for a supplement to boost energy levels beyond anything you have ever experienced before look no further, Stizm - Extreme Energy Inducing Formula has arrived. Order yours today, supplies are limited. Stizm can be stacked with Dicana for dramatic weight loss.
Stizm is a serious stimulant and not for the faint of heart. Please read all warnings before use.
RESEARCH DATA
Caffeine
Caffeine is the most consumed drug in the world. Chemically, caffeine is 1,3,7-trimethylxanthine -- meaning it is a xanthine molecule with methyl groups replacing all of the three hydrogens bound to nitrogens in the xanthine ring. Xanthines are very potent antioxidants and in numerous studies they have proven to have great potency in protecting cells from oxidative damage.
Of the 3 xanthines, caffeine is the one with the strongest action on the CNS. It’s mechanism of action is primarily due to antagonism of adenosine and secondly due to inhibition of the phosphodiesterase enzyme which breaks up cAMP into adenosine and monophosphoric acid. Caffeine's antagonism of adenosine action on A2A receptors decreases release of the inhibitory neurotransmitter GABA. Apart from it’s effect on the CNS, caffeine also is the strongest xanthine in promoting muscular performance. Majority of published evidence supports the notion that caffeine is ergogenic during prolonged (> 30 min), moderate intensity (approximately 75 to 80% VO2max) exercise. Suggested mechanisms for this action are (a) increased myofilament affinity for calcium and/or increased release of calcium from the sarcoplasmic reticulum in skeletal muscle; (b) cellular actions caused by accumulation of cyclic-3',5'-adenosine monophosphate (cAMP) in various tissues including skeletal muscle and adipocytes; and (c) cellular actions mediated by competitive inhibition of adenosine receptors in the central nervous system and somatic cells. Caffeine also promotes lypolisis and thermogenesis. It’s effects on BP are mixed, since the CNS stimulation increases BP while the peripheral vasolidation decreases BP. Chronic caffeine consumption hasn’t shown to be a risk factor for hypertension or CVS disease.
Theobromine
Unlike caffeine which is naturally present in many plants, theobromine exists almost exclusively in cocoa. It generally has a much weaker effect on the CNS than caffeine but current research shows that it might play an important role in the mood-enhancing effects of chocolate. It is however a very potent diuretic which can rapidly lower blood pressure, increase insulin sensitivity and has an antiplatelet and cardioprotective effect.
Synephrine
Synephrine is naturally found in the Citrus aurantium plants. A wide variety of citrus materials containing synephrine are used in Chinese medicine and have generally been regarded as non-toxic; Synephrine is a direct alpha and beta adrenergic agonist, differing from adrenaline only in the lack of the m-hydroxyl group. This results in greater action in the CNS than adrenaline, since it makes the molecule less hydrophilic and more capable of bypassing the blood brain barrier. Also it means that Synephrine has an extended half-life in comparison to adrenaline, as it cannot be metabolized by COMT . The methyl substitution at the N molecule gives synephrine equal alpha and beta agonistic action. Testing showed that when given by i.v. infusion to healthy volunteers at a rate of 4 mg/minute, synephrine increases systolic and mean arterial blood pressure, increases cardiac index, and decreases peripheral vascular resistance resulting in enhanced heart performance.
Tyramine
Tyramine is a trace amine found naturally in the body, as well as many "old" foods, like salami, cheese, red wine, e.t.c. Tyramine acts by replacing catecholamins like adrenaline and dopamine in the post-senaptic neurons, thus resulting in catecholamine release. Recent research indicates that tyramine might also act as a neurotransmitter. This hypothesis comes from the discovery of a G protein-coupled receptor with high affinity for tyramine called TA1.
Octopamine
Just like synephrine which stands apart from adrenaline only due the reduction of an –OH group, octopamine is almost similar to noradrenalin, with the exclusion of a phenolic hydroxyl group. This makes the molecule more capable to bypass the blood brain barrier and affect the C.N.S. compared to normal noradrenalin. Also the lack of a methyl group at the nitrogen, gives it equal alpha and beta adrenergic properties. Because it lacks the m-placed hydroxyl group, octopamine, like synephrine, isn’t metabolized by COMT, thus having a longer half-life and bioavailability. Indeed, in animal in-vivo studies oral octopamine has demonstrated capability to stimulate both alpha and beta adrenergic receptors. However it quite selectively stimulates beta-3 adrenergic receptors, which promote lipolysis, instead of beta-1 and beta-2 receptors. In animal studies, octopamine has also demonstrated capability to elevate mood, increase blood pressure and enhance locomotor activity.
Hordenine
Hordenine is a naturally present amine in many roots of plants of the Graminae family. The lack of a hydroxyl group in the carbon chain gives it indirect sympathomemetic abilities, like amphetamine. The dymethylation of the nitrogen atom also gives it slight MAO inhibiting properties, but hordenine seems to be a selective MAO-B inhibitor. MAO-B metabolizes dopamine and thus it’s inhibition has no great effect in blood pressure, but can elevate mood. Experiments in intact animals (rats, dogs) show that hordenine has a positive inotropic effect upon the heart, increases systolic and diastolic blood pressure, peripheral blood flow volume, inhibits gut movements but has no effect upon the psychomotorical behaviour of mice. Also hordenine is a very potent diuretic and although it can initially heighten blood pressure, over time it’s diuretic effect lowers blood pressure.
Phenylethylamine(PEA)
Of all the endogenous trace amines, phenylethylamine is the one most closely structural to amphetamine. It is a major psychotropic constituent of chocolate and is speculated to be released in great amounts by the brain when in love. Recent research has identified 15 members of two distinct families of G protein-coupled receptors with a high degree of similarity to traditional G protein-coupled biogenic amine receptors. It was demonstrated that one of these receptors, called TA1, is a receptor for two of the trace amines, â-phenylethylamine and tyramine. TA1 binds to both â-phenylethylamine and tyramine with high affinity and produces cAMP in response to this binding, whereas the related TA2 receptor appears to be specific for â-phenylethylamine and tryptamine. Both of these G protein-coupled receptor families possess many of the structural hallmarks of the rhodopsin/â-adrenergic receptor superfamily. Apart from affecting it’s own receptors, phenylethylamine can also enhance the impulse-propagation mediated release of catecholamine and serotonin, although research has indicated that tryptamine possesses greater capability of promoting serotonin release(thus elevating mood) while PEA promotes noradrenaline release(thus stimulating the CNS). Phenylethylamine has shown in research to elevate mood but the biggest challenge has been it’s relatively low half life, since it is rapidly metabolized by MAO-B. However the inclusion of a MAO-B inhibitor like hordenine can lengthen it’s half-life and effectiveness.
SUGGESTED USAGE
As an adult dietary supplement take two capsules with 8 ounces of water 30-45 minutes before your workout or whenever an increase in energy or mental clarity is desired.
Warning: Not intended for use by anyone under the age of 18. Do not use this product if you are pregnant, nursing or contemplating pregnancy. Do not use this product if you have any medical condition especially heart disease, thyroid disease, diabetes, high blood pressure, psychiatric condition, difficulty in urinating, prostate enlargement, or seizure disorder, if you are using a monoamine oxidase inhibitor (MAOI) or any other prescription drug, or you are using an over-the-counter drug containing ingredients found in certain allergy, asthma, cough/cold and weight control products.
The recommended dose of this product contains caffeine and should not be taken by individuals wishing to eliminate caffeine from their diet. Limit use of caffeine-containing foods and beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally, rapid heartbeat.
Exceeding recommended serving will not improve results.
Discontinue use and call a health care professional immediately if you experience rapid heartbeat, dizziness, severe headache, shortness of breath, or other similar symptoms.
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Stizm -
Extreme Energy Inducing Formula, 90 caps, (Thermolife)
Caffeine 250mg
Theobromine 200mg
Synephrine HCL 100mg
Octopamine 100mg
Hordenine 100mg
Tyramine HCL 100mg
Phenylethylamine 50mg
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Stizm -
Extreme Energy Inducing Formula, 90 caps, (Thermolife)
Editor's rating: 7.5 out of 10
User's rating:  0%  0%
USER'S OPINION
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Stizm -
Extreme Energy Inducing Formula, 90 caps, (Thermolife)
GUARANTEE/ SHIPPING INFORMATION
Stizm is shipped in a discrete, unmarked package. Orders are processed immediately and usually take about 3 to 5 working days to be received. We do ask that you try it for 2 to 3 weeks to feel the full effects. Any information received is used only for order processing and shipping purposes. Your information, such as e-mail address, will never be disclosed to a third party.
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Stizm -
Extreme Energy Inducing Formula, 90 caps, (Thermolife)
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